Involvement of ATP in Radiation-induced Bystander Effect as a Signaling Molecule
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چکیده
منابع مشابه
Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect.
Radiation-induced bystander effect represents a paradigm shift in our understanding of the radiobiological effects of ionizing radiation in that extranuclear and extracellular effects may also contribute to the final biological consequences of exposure to low doses of radiation. Evidence suggests that targeted cytoplasmic irradiation results in mutation in the nucleus of the "hit" cells and tha...
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Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects. Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent years. RIBE occurs in unexposed cells which are related to adjacent or distant irradiated cells. RIBE contradict with "target theory" which necessitates radiation tr...
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The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...
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Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, incl...
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Although radiation-induced bystander effects have been well described over the past decade, the mechanisms of the signaling processes involved in the bystander phenomenon remain unclear. In the present study, using the Columbia University charged particle microbeam, we found that mitochondrial DNA–depleted human skin fibroblasts (R) showed a higher bystander mutagenic response in confluent mono...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2014
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.14-00034